Centers for Medical Countermeasures Against Radiation Consortium (CMCRC)

Annual Meeting 2023-2024

January 16-17, 2024

RNCP, NIAID, NIH

IMPORTANT NOTICE: 

As of late January 15, 2024, this hybrid meeting has changed to ALL VIRTUAL due to inclement weather conditions. A virtual link has been sent out to all attendees. 

 

AGENDA 

 

Day 1:  Tuesday, January 16, 2024

8:30 am  Check-in & A/V testing

9:00 am  Welcome remarks from NIAID - Lanyn Taliaferro, PhD - NIAID CMCRC Project Scientist

 

CMCRC Program-Wide Cores

9:10 am  Overview of Consortium-wide Coordinating Core:  Yuji Zhang, PhD 

9:20 am  Overview of Opportunities Fund Management Core: Sally Amundson, PhD

9:30 am  Q&A

     

Duke University CMCRC – Nelson Chao, PI (9:35-11:20am)
 

9:35 am  Overview of Center & Project 1:  Nelson Chao, MD – Duke University School of Medicine

CaMKK2 a novel target to mitigate radiation-induced injury of the hematopoietic system and the gastrointestinal tract.

10:00 am       Project 2:  Benny (Jun) Chen, MD – Duke University School of Medicine

Endothelial Cell-Derived Extracellular Vesicles for Mitigation of the Hematopoietic Acute Radiation Syndrome.

10:20 am       Project 3:  Jenny Ting, PhD – University of North Carolina School of Medicine 

                 Innate immune receptor ligand and the microbiota as countermeasures for radiation

10:40 am       Project 4:  David Kirsch, MD, PhD – University of Toronto 

     Dissecting the Role of Revival Stem Cells in the Radiation-Induced Gastrointestinal   

     Syndrome to Define Targets for Mitigation.

11:00 am       Discussion/Q&A - External Advisors and Other Members

11:20 pm       BREAK

11:30 am       Gayle E Woloschak, PhD, FASTRO - Northwestern University 

     Studies on Radiological Exposures and Mitigation of Internal Exposures

12:25 am   Q&A

12:30 pm       LUNCH 

 

Columbia University CMCRC – David Brenner, PI (1:30-3:00pm)

1:30 pm  Overview of Center & Project 1:   David Brenner, PhD – Columbia University

                 Overview of Center, and Project 1 (high throughput cytogenetics)

2:00 pm  Project 2:   Sally Amundson, PhD – Columbia University

Radiation biodosimetry using gene expression signatures

2:20 pm  Project 3:   Albert Fornace, MD presenting on behalf of Evagelia C Laiakis, PhD – Georgetown University

                 Rapid non-invasive radiation biodosimetry through metabolomics 

2:40 pm  Discussion by External Advisors and Other Members:  Q & A

3:00 pm  BREAK

 

University of Maryland School of Medicine CMCRC – France Carrier, PI (3:15-5:05pm)

3:15 pm  Overview of Center & Project 4: France Carrier, PhD – University of Maryland School of Medicine

Overview: INTERACT: Inter-collaborative Radiation Countermeasures Consortium Accomplishment and Vision Beyond 2025

 

             Project 4 – “Characterizing senescence following Partial Body Irradiation”

3:45 pm  Project 1: Christie Orschell, PhD – Indiana University School of Medicine 

                 Development of prostaglandins as medical countermeasures for H-ARS and DEARE

4:05 pm  Project 2: Sue Chin Lee (representing Gabor Tigyi, PhD – The University of Tennessee Health Science Center) 

                 Advances in developing Radioprotectin-1

4:25 pm  Project 3: Paul Okunieff, MD – University of Florida College of Medicine

Evaluation of basic fibroblast growth factor mimetic peptide as a mitigator of GI-ARS and H-ARS in a Wistar Rat Model

4:45 pm  Discussion by External Advisors and Other Members:  Q & A

5:05 pm  Wrap-up – Andrea Dicarlo, PhD (Director of RNCP) 

5:15 pm         Day One Adjourned 

 

------------------------------------------------------------------------------------------------------------------------------

Centers for Medical Countermeasures Against 

Radiation Consortium (CMCRC) 

Annual Meeting 2023-2024

January 16-17, 2024

RNCP, NIAID, NIH

Day 2:  Wednesday, January 17, 2024

8:30 am  Check-in & A/V testing

9:00 am  NIAID Overview of CMCRC

9:15 am  Dave T. Yeung, PhD – NIAID Chemical Countermeasures Research Program

                 An Introduction to the Chemical Countermeasures Research Program (CCRP)

9:30 -11:30 am - Collaborative Projects Presentations 

Collaboration 1: Investigating Neutron-induced Lung Injury

9:30 am Guy Garty, PhD, Columbia University

    France Carrier, PhD, University of Maryland 

9:55 am Q&A

Collaboration 2: Evaluation of the Role of intestinal stem cell (ISC) subsets in promoting recovery from radiation injury underlying the acute gastrointestinal radiation syndrome (GI-ARS)

10:00 am    Sue Chin Lee, PhD (representing Gabor Tigyi, PhD – The University of Tennessee Health Science Center) 

                Andrea Finholt-Daniel,PhD – Duke University School of Medicine 

10:25 am Q&A

Collaboration 3: First studies determining the efficacy of countermeasures against radiation doses delivered in microseconds 

10:30 am Brian Ponnaiya, PhD – Columbia University

10:55 am Q&A

11:00 am       BREAK

 

Day 2 CMCRC Retreat - Closed Session

(PIs, Core Directors, NIAID Program Staff & External Advisors only)

 

11:10 am       Feedback from EAB Advisors  

11:30 am       Open Discussion (How to store the data and website content; future paths)

12:30 pm      Wrap up of Closed Session

 

Many thanks to the members of the CMCRC External Advisory Board for their valuable contributions to the consortium: 

 

Jeffrey Buchsbaum, MD - NCI, NIH

Polly Chang, PhD - SRI

Nicholas Dainiak, MD - Yale School of Medicine

Daniela Stricklin, PhD - FDA/CDRH