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Article: “Application of the cytokinesis-block micronucleus assay for high dose exposures using imaging flow cytometry: CBMN assay for high dose exposures using imaging flow cytometry”
Drs. David J Brenner, Helen C Turner, and colleagues investigate the application of the cytokinesis-block micronucleus assay for high dose exposures using imaging flow cytometry. [Cytogenet Genome Res. 2023 Aug 1. doi: 10.1159/000532124. Online ahead of print.]
Lindsay A Beaton-Green, Jessica M Mayenburg, Leonora Marro, Eman Hassan, Sarita Cuadros Sanchez, Riham Darwish, Sylvie Lachapelle, Nadine Adam, Julie J Burtt, Cyndi Van Den Hanenberg, Matthew A Rodrigues, Qi Wang, David J Brenner, Helen C Turner, Ruth Wilkins
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Publication: “MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia” Dr. Joel Greenberger and colleagues report that MYC overexpression impairs HSPC function in FA patients and contributes to exhaustion in FA bone marrow. [29Sept2020 Cell Stem Cell]
Alfredo Rodríguez, Kaiyang Zhang, Anniina Färkkilä, Jessica Filiatrault, Chunyu Yang, Martha Velázquez, Elissa Furutani, Devorah C Goldman, Benilde García de Teresa, Gilda Garza-Mayén, Kelsey McQueen, Larissa A Sambel, Bertha Molina, Leda Torres, Marisol González, Eduardo Vadillo, Rosana Pelayo, William H Fleming, Markus Grompe, Akiko Shimamura, Sampsa Hautaniemi, Joel Greenberger, Sara Frías, Kalindi Parmar, Alan D D'Andrea
Read more: MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia |
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Article: “Establishing Pediatric Mouse Models of the Hematopoietic Acute Radiation Syndrome and the Delayed Effects of Acute Radiation Exposure” Drs. Christie Orschell, Thomas MacVittie, and colleagues have identified a pediatric mouse model useful for assessing the efficacy of medical countermeasures (MCMs) against acute radiation syndrome (ARS) and delayed effects of acute radiation exposure (DEARE) in children. [12Feb2020 Radiation Research] Andrea M Patterson, Rajendran Sellamuthu, P Artur Plett, Carol H Sampson, Hui Lin Chua, Alexa Fisher, Sasidhar Vemula, Hailin Feng, Barry P Katz, Gregory Tudor, Steven J Miller, Thomas J MacVittie, Catherine Booth, Christie M Orschell Read more: |
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Publication: “Characterization of cardiovascular injury in mice following partial-heart irradiation with clinically relevant dose and fractionation” Dr. David G Kirsch and colleagues developed and characterized a mouse model of radiation-induced heart disease that mimics the dose, fractionation, and beam arrangement of left breast and chest wall radiation therapy. [02Feb2021 Radiother Oncol.] Highlights
Chang-Lung Lee, Jessica Lee, Andrea R Daniel, Matt Holbrook, Stephanie Hasapis, Ato O Wright, Jeremy Brownstein, Lorraine Da Silva Campos, Yan Ma, Dennis Abraham, Cristian T Badea, David G Kirsch
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Publication: “Optimizing and Profiling Prostaglandin E2 as a Medical Countermeasure for the Hematopoietic Acute Radiation Syndrome” Dr. Christie Orschell and colleagues have identified windows of administration for significant radio-mitigation and radioprotection by dmPGE2 in the hematopoietic acute radiation syndrome (H-ARS); demonstrated survival efficacy in special populations; and gained insight into radioprotective mechanisms, information useful towards development of dmPGE2 as a medical counter measure (MCM) for first responders, military personnel, and civilians facing radiation threats. [10Dec2020 Radiation Research] Andrea M Patterson, Tong Wu, Hui Lin Chua, Carol H Sampson, Alexa Fisher, Pratibha Singh, Theresa A Guise, Hailin Feng, Jessica Muldoon, Laura Wright, P Artur Plett, Louis M Pelus, Christie M Orschell Read more: |
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Publication: “Fostering Radiation Oncology Physician Scientist Trainees within a Diverse Workforce: The Radiation Oncology Research Scholar Track”
Dr. David G Kirsch and colleagues created the Duke Radiation Oncology Research Scholar (RORS) Program to foster the development of independent physician scientists and encourage other Radiation Oncology residency programs at peer institutions to consider similar program. [03Jan2021 Int J Radiat Oncol Biol Phys]
Joseph K Salama, Scott R Floyd, Christopher G Willett, David G Kirsch Read more: |
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Article: “Improved Ultraviolet Radiation Film Dosimetry Using OrthoChromic OC-1 Film” Drs. David Welch and David Brenner investigate the use of commercially available OrthoChromic OC-1 film, to measure ultraviolet radiation exposure. [09Dec2020 Photochem Photobiol] David Welch, David J. Brenner
Read more: Improved Ultraviolet Radiation Film Dosimetry Using OrthoChromic OC-1 Film |
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Publication: “Commonalities Between COVID-19 and Radiation Injury” Drs. Carmen Rios, Andrea DiCarlo, Lanyn Taliaferro, and colleagues discuss the medical countermeasures for acute radiation syndrome (ARS) in the event of a radiation public health emergency and point to how the intersection between COVID-19 and ARS may accelerate the discovery of treatments for both. [16Oct2020 Radiat Res.] Carmen I. Rios; David R. Cassatt; Brynn A. Hollingsworth; Merriline M. Satyamitra; Yeabsera S. Tadesse; Lanyn P. Taliaferro; Thomas A. Winters; Andrea L. DiCarlo
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Publication: “The Impact of Radiation Energy on Dose Homogeneity and Organ Dose in the Göttingen Minipig Total-Body Irradiation Model” Drs. Isabel Jackson, Zeljko Vujaskovic, and colleagues evaluate the effect of varying the radiation energy in the absorbed dose delivered to individual organs by total body irradiation (TBI) of eight Göttingen minipigs of varying weights and dimensions. [12Oct2020 Radiation Research] Yannick Poirier, Stewart Becker, Cristina Decesaris, Wesley Culberson, Emily Draeger, Andrew J. Gerry, Christopher D. Johnstone, Allison Gibbs, Zeljko Vujaskovic, Isabel L. Jackson Read more: |
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Publication: “VADER: A Variable Dose-Rate External 137Cs Irradiator for Internal Emitter and Low Dose Rate Studies” Drs. Guy Garty, Evagelia Laiakis, Sally Amundson, David Brenner, and colleagues present the study on VADER (VAriable Dose-rate External 137Cs irradiatoR) design and characterization of its performance over 18 months of use. [16Nov2020 Scientific Reports] Guy Garty, Yanping Xu, Gary W. Johnson, Lubomir B. Smilenov, Simon K. Joseph, Monica Pujol-Canadell, Helen C. Turner, Shanaz A. Ghandhi, Qi Wang, Rompin Shih, Robert C. Morton, David E. Cuniberti, Shad R. Morton, Carlos Bueno-Beti, Thomas L. Morgan, Peter F. Caracappa, Evagelia C. Laiakis, Albert J. Fornace Jr., Sally A. Amundson & David J. Brenner Read more: VADER: a Variable Dose-Rate External 137Cs Irradiator for Internal Emitter and Low Dose Rate Studies
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Publication: “Low-Dose Radiation Therapy (LDRT) for COVID-19: Benefits or Risks?” Drs. Andrea DiCarlo, David Kirsch, and colleagues provide guidance to clinicians and researchers who plan to conduct preclinical and clinical studies for using low-dose radiation therapy (LDRT) as a treatment for COVID-19. [12Oct2020 Radiat Res.] Pataje G. Prasanna, Gayle E. Woloschak, Andrea L. DiCarlo, Jeffrey C. Buchsbaum, Dörthe Schaue, Arnab Chakravarti, Francis A. Cucinotta, Silvia C. Formenti, Chandan Guha, Dale J. Hu, Mohammad K. Khan, David G. Kirsch, Sunil Krishnan, Wolfgang W. Leitner, Brian Marples, William McBride, Minesh P. Mehta, Shahin Rafii, Elad Sharon, Julie M. Sullivan, Ralph R. Weichselbaum, Mansoor M. Ahmed, Bhadrasain Vikram, C. Norman Coleman, Kathryn D. Held Read more: Low-Dose Radiation Therapy (LDRT) for COVID-19: Benefits or Risks?
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Article: “Dose and Dose-Rate Effects in a Mouse Model of Internal Exposure from 137Cs. Part 2: Integration of Gamma-H2AX and Gene Expression Biomarkers for Retrospective Radiation Biodosimetry” Drs. Igor Shuryak, Sally Amundson, David Brenner, and colleagues assess the feasibility and possible advantages of combining γ-H2AX with transcriptomics to improve 137Cs activity reconstructions. [16Oct2020 Radiat Res.] [online ahead of print] Igor Shuryak, Shanaz A Ghandhi, Helen C Turner, Waylon Weber, Dunstana Melo, Sally A Amundson, David J Brenner Read more: |
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Article: “Use of CT simulation and 3-D radiation therapy treatment planning system to develop and validate a total-body irradiation technique for the New Zealand White rabbit” Drs. Isabel Jackson, Zeljko Vujaskovic, and colleagues developed a simple, convenient, robust and accurate technique for validating total body irradiation (TBI) exposure of the New Zealand White rabbit. [14Sept2020 International Journal of Radiation Biology] Yannick Poirier, Charlotte Prado, Karl Prado, Emily Draeger, Isabel L Jackson, Zeljko Vujaskovic Read more:
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Article: “Multi-omics Analyses of Radiation Survivors Identify Radioprotective Microbes and Metabolites” Drs. Jenny Ting, Nelson Chao, and colleagues observe that elevated bacterial taxa lachnospiraceae and enterococcaceae were associated with postradiation restoration of hematopoiesis and gastrointestinal repair. [30Oct2020 Science] Hao Guo, Wei-Chun Chou, Yunjia Lai, Kaixin Liang, Jason W. Tam, W. June Brickey, Liang Che, Nathan D. Montgomery, Xin Li, Lauren M. Bohannon, Anthony D. Sung, Nelson J. Chao, Jonathan U. Peled, Antonio L. C. Gomes, Marcel R. M. van den Brink, Matthew J. French, Andrew N. Macintyre, Gregory D. Sempowski, Xianming Tan, R. Balfour Sartor, Kun Lu, Jenny P. Y. Ting Read more: Multi-omics Analyses of Radiation Survivors Identify Radioprotective Microbes and Metabolites
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